PCMC was created by PD 1631 on August 10, 1979 Later amended by EO 893 on April 23, 1983 and was originally LUNGSOD NG KABATAAN. It was inaugurated on April 29, 1980 and started operation on June 30, 1980 under the Ministry of Human Settlements. Renamed the PHILIPPINE CHILDREN’S MEDICAL CENTER by Malacañang Memorandum Order No. 4 dated November 12, 1986, it was administratively attached to the Department of Health along with three other subspecialty centers, Philippine Heart Center, Lung Center of the Philippines and the National Kidney and Transplant Institute.

It was established for the purpose of conducting clinical research on diseases afflicting Filipino children, manage the most difficult and complex clinical cases with preferential attention to the poor, and train pediatric specialists and sub-specialists for deployment to underserved areas outside of Metro Manila. PCMC is the biggest tertiary subspecialty hospital. It offers the most comprehensive tertiary-care services for children in the country. PCMC is also respected for its paramount and comprehensive pediatric training program with a full competent and dedicated staff of general pediatricians and sub-specialists, nurses and support services, with a well-established referral network system. Through the concerted efforts of its dedicated staff from every department, quality patient care has been consistently provided. Preventive health programs both for patients and employees were implemented and sustained, and subspecialty services further expanded. PCMC is also the home of top clinical practitioners and leaders in Philippine Pediatrics who are the same practitioners in top privately owned hospitals.

FUNCTIONS (Per P.D. No. 1631):
1. To construct, establish, operate and maintain facilities for the children’s welfare, including a specialized hospital for children;
2. To promote, encourage and engage in scientific research on the prevention of pediatric diseases and the care and/or treatment of
pediatric patients and related activities, including sponsorship and conduct of relevant congresses, conventions, seminars, and conferences;
3. To stimulate and/or underwrite scientific researches on biological, demographic, social, economic, eugenic, physiological aspects of pediatric disorders and abnormalities and their control; and gather, compile, and publish the findings of such researches for public dissemination;
4. To facilitate and encourage the dissemination and exchange of ideas and information on the prevention, treatment and control of pediatric diseases; to arouse, enhance and develop public interest in children, general health and physical fitness, especially on the promotion of health and rehabilitation, and other relevant or related fields;
5. To encourage and/or undertake the training of physicians, nurses, medical technicians, health officers and social workers on the practical and scientific conduct and implementation of pediatric services;
6. To assist universities, hospitals and research institutions in their studies of congenital and acquired anomalies, to encourage advanced training on matters of, or affecting the child, and related fields and to support educational programs of value to general health;
7. To encourage the formation of other organizations on the national, provincial, city, municipal or barangay level and to coordinate their various efforts and activities for the purpose of achieving a more effective approach to the common problem relative to the objectives herein enumerated; and
8. To extend pediatric services to the general public, to help prevent, relieve or alleviate the afflictions and maladies of children and youth specially the poor and less fortunate in life, without regard to race, creed, color or political belief.